Shift: No Department: HC-RD-XO4 Oligonucleotide Chemical Conjugation Recruiter: Beverly Dellisola
This information is for internals only. Please do not share outside of the organization.
Your Role:
The Oligonucleotide Therapeutics group is seeking a highly motivated and collaborative Scientist to support the discovery, characterization, and optimization of oligonucleotide therapeutics across a range of disease areas. This role is intended for an experimental molecular and cellular biologist who combines a strong foundation in RNA biology with hands-on experience in cell-based assay development, mechanistic studies, and translational research. In this role, you will help advance novel oligonucleotide therapeutics from early discovery toward preclinical development by developing robust in vitro assays, generating high-quality biological data, and contributing to the selection of next-generation therapeutic candidates.
You will be responsible for designing, executing, and optimizing cellular and molecular biology workflows to evaluate oligonucleotide activity, including target engagement, mRNA knockdown, protein modulation, and mechanism of action. You will establish quantitative molecular biology workflows, optimize cell-based assay platforms, and apply data-driven insights to support candidate prioritization and translational decision-making. Working closely with chemistry, formulation, and translational research teams, you will help evaluate novel oligonucleotide sequences, chemical modifications, and delivery strategies while contributing to the advancement of our oligonucleotide therapeutic platform.
Responsibilities:
Design, execute, and optimize in vitro assays to evaluate oligonucleotide (ASO, siRNA, LNA) activity, including target engagement, mRNA knockdown, protein modulation, and splice-switching in disease-relevant cell models.
Establish, optimize, and validate molecular biology workflows including RT-qPCR, Western blotting, flow cytometry, immunofluorescence microscopy, and other cell-based assays to support therapeutic discovery.
Develop and characterize cellular models to assess oligonucleotide uptake, intracellular trafficking, pharmacodynamic responses, and mechanism of action.
Don't want to miss the next one?
Subscribe to daily email alerts for roles matching your interests.
Perform dose-response and time-course studies to evaluate oligonucleotide potency, durability, and pharmacological activity.
Analyze experimental data, identify trends, troubleshoot technical challenges, and recommend next-step experiments to advance lead optimization.
Collaborate with multidisciplinary teams, including chemistry, formulation, and bioinformatics, to evaluate oligonucleotide sequences, chemical modifications, and delivery strategies.
Support implementation of laboratory automation and high-throughput workflows to improve assay robustness, reproducibility, and efficiency.
Maintain accurate experimental records and document procedures, results, and conclusions in accordance with internal standards and good laboratory practices.
Present scientific findings at project team meetings and contribute to internal reports, scientific presentations, and publications.
Maintain a safe, organized laboratory environment while adhering to company safety policies and laboratory best practices.
Minimum Qualifications:
PhD in Molecular Biology, Cell Biology, RNA Biology, Biochemistry, Pharmacology, or other Scientific discipline with 1+ years of experience with oligonucleotide therapeutics, including ASOs, siRNA, miRNA, splice-switching oligonucleotides, or similar RNA-targeting technologies
OR
Master’s degree in Molecular Biology, Cell Biology, RNA Biology, Biochemistry, Pharmacology, or other Scientific discipline with 3+ years of experience with oligonucleotide therapeutics, including ASOs, siRNA, miRNA, splice-switching oligonucleotides, or similar RNA-targeting technologies
Preferred Qualifications:
Experience culturing and maintaining mammalian cell lines and developing robust cell-based assays for therapeutic discovery
Strong experience developing and executing cell-based assays to evaluate target engagement, gene expression, and pharmacodynamic endpoint
Proficiency in molecular and cellular biology techniques including RT-qPCR, Western blotting, ddPCR, ELISA/MSD immunoassays, flow cytometry, fluorescence microscopy, and mammalian cell culture
Experience designing, optimizing, and executing medium- to high-throughput cell-based screening assays using multiple mammalian cell lines to evaluate oligonucleotide potency, target engagement, and pharmacodynamic responses
Familiarity with oligonucleotide chemical modifications, delivery technologies, and mechanism-of-action studies
Experience with laboratory automation, high-throughput screening, or Design of Experiments (DoE)
Knowledge of translational biomarkers, pharmacodynamic assays, and target engagement strategies
Demonstrated ability to independently design experiments, analyze complex datasets, troubleshoot technical challenges, and communicate scientific findings
Excellent organizational, written, and verbal communication skills
Ability to work effectively in a collaborative, cross-functional research environment
Pay Range for this position: $95,900 - $143,800
The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here
The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.
Similar roles you might like
More openings like this one — take a look before you go.
