Senior Data Scientist

Career Category

Clinical

What you will do

Let's do this. Let's change the world. We are seeking a Senior Data Scientist to join the AI & Data for Engineered Biologics team within Amgen's Large Molecule Discovery (LMD) organization. In this vital role, you will advance data-driven prediction and design of fit-for-purpose proteins by developing machine learning models that connect sequence, structure, biophysical measurements, and experimental outcomes to biomolecular developability and structural tractability. Your work will reduce reliance on trial-and-error workflows, improve the probability of experimental success, and guide construct and condition selection for large-molecule discovery.

The successful candidate will work in a highly collaborative, multidisciplinary environment, partnering with protein scientists, structural biologists and ML engineers to support decisions from early design through sample generation and structural characterization.

KEY RESPONSIBILITIES

- Develop and apply machine learning models to predict sequence-to-property relationships.

- Develop scalable, reproducible data-processing, feature-generation, model-training, and evaluation workflows for large-scale biological datasets.

- Design, implement and train state-of-the-art foundation models including protein language models, diffusion models, or other generative approaches using multimodal biological data.

- Develop interpretable and uncertainty-aware modeling approaches that quantify confidence and support decision-making.

- Apply active learning and Bayesian optimization to guide experimental design and iterative improvement of protein design workflows.

- Collaborate cross-functionally with experimental teams to define modeling objectives, prioritize experiments, and interpret results.

- Communicate scientific findings clearly through presentations, written summaries and discussions with technical and non-technical stakeholders.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a Senior Data Scientist with these qualifications.