Scientist - Oligonucleotide Biology
Merck Electronics
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United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.
This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.
Your Role:
The Oligonucleotide Therapeutics group is seeking a highly motivated and collaborative Scientist to support the discovery, characterization, and optimization of oligonucleotide therapeutics across a range of disease areas. This role is intended for an experimental molecular and cellular biologist who combines a strong foundation in RNA biology with hands-on experience in cell-based assay development, mechanistic studies, and translational research. In this role, you will help advance novel oligonucleotide therapeutics from early discovery toward preclinical development by developing robust in vitro assays, generating high-quality biological data, and contributing to the selection of next-generation therapeutic candidates.
You will be responsible for designing, executing, and optimizing cellular and molecular biology workflows to evaluate oligonucleotide activity, including target engagement, mRNA knockdown, protein modulation, and mechanism of action. You will establish quantitative molecular biology workflows, optimize cell-based assay platforms, and apply data-driven insights to support candidate prioritization and translational decision-making. Working closely with chemistry, formulation, and translational research teams, you will help evaluate novel oligonucleotide sequences, chemical modifications, and delivery strategies while contributing to the advancement of our oligonucleotide therapeutic platform.
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